Clinical Imaging
Volume 34, Issue 1 , Pages 20-28 , January 2010

Detection of nodal metastatic disease in patients with non-small cell lung cancer: comparison of positron emission tomography (PET), contrast-enhanced computed tomography (CT), and combined PET-CT

  • Elisa Ventura

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • ,
  • Tina Islam

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • Corresponding Author InformationCorresponding author. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
    • ,
  • Michael S. Gee

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Umar Mahmood

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Marta Braschi

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Mukesh G. Harisinghani

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA

Received 6 March 2009 ,Accepted 10 March 2009.

References 

  1. American Cancer society. Statistics for 2006. Access at http://www.cancer.org/docroot/stt/stt_0.asp
  2. Yi CA, Lee KS, Kim BT, et al. Efficacy of helical dynamic CT versus integrated PET/CT for detection of mediastinal nodal metastasis in non-small cell lung cancer. Am J Roentgenol. 2007;188(2):318–325
  3. Glazer GM, Gross BH, Quint LE, Francis IR, Bookstein FL, Orringer MB. Normal mediastinal lymph nodes: number and size according to American Thoracic Society mapping. Am J Roentgenol. 1985;144:261–265
  4. Genereux GP, Howie JL. Normal mediastinal lymph node size and number: CT and anatomic study. Am J Roentgenol. 1984;142:1095–1100
  5. Gamez C, Rosell R, Fernandez A, et al. PET/CT fusion scan in lung cancer: current recommendations and innovations. J Thorac Oncol. 2006;1(1):74–77
  6. Gupta NC, Tamim WJ, Graeber GG, Bishop HA, Hobbs GR. Mediastinal lymph node sampling following positron emission tomography with fluorodeoxyglucose imaging in lung cancer staging. Chest. 2001;120:521–527
  7. Steinert HC, Hauser M, Allemann F, et al. Non-small cell lung cancer: nodal staging with FDG PET versus CT with correlative lymph node mapping and sampling. Radiology. 1997;202:441–446
  8. Vansteenkiste JF, Stroobants SG, De Leyn PR, et al. Lymph node staging in non-small-cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients. J Clin Oncol. 1998;16(6):2142–2149
  9. Mountain CF, Dresler CM. Regional lymph node classification for lung cancer staging. Chest. 1997;111(6):1718–1723
  10. Naruke T, Suemasu K, Ishikawa S. Lymph node mapping and curability of various levels of metastasis in resected lung cancer. J Thorac Cardiovasc Surg. 1978;76:832–839
  11. Devaraj A, Cook GJR, Hansell DM. PET/CT in non-small cell lung cancer staging—promises and problems. Clin Radiol. 2007;62(2):97–108
  12. Halpern BS, Schiepers C, Weber WA, et al. Presurgical staging of non-small cell lung cancer: positron emission tomography, integrated positron emission tomography/CT, and software image fusion. Chest. 2005;128(4):2289–2297
  13. Shim SS, Lee KS, Kim BT, et al. Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging. Radiology. 2005;236(3):1011–1019
  14. McLoud TC, Bourgouin PM, Greenberg RW, et al. Bronchogenic carcinoma: analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. Radiology. 1992;182:319
  15. Scott WJ, Gobar LS, Terry JD, Dewan NA, Sunderland JJ. Mediastinal lymph node staging of non-small-cell lung cancer: a prospective comparison of computed tomography and positron emission tomography. J Thorac Cardiovasc Surg. 1996;111(3):642–648
  16. von Haag DW, Follette DM, Roberts PF, Shelton D, Segel LD, Taylor TM. Advantages of positron emission tomography over computed tomography in mediastinal staging of non-small cell lung cancer. J Surg Res. 2002;103(2):160–164
  17. Bury T, Paulus P, Dowlati A, et al. Staging of the mediastinum: value of positron emission tomography imaging in non-small cell lung cancer. Eur Respir J. 1996;9:2560–2564
  18. Takamochi K, Yoshida J, Murakami K, et al. Pitfalls in lymph node staging with positron emission tomography in non-small cell lung cancer patients. Lung Cancer. 2005;47(2):235–242
  19. Kapoor V, McCook BM, Torok FS. An introduction to PET-CT imaging. Radiographics. 2004;24(2):523–543
  20. Cerfolio RJ, Ojha B, Bryant AS, Raghuveer V, Mountz JM, Bartolucci AA. The accuracy of integrated PET-CT compared with dedicated PET alone for the staging of patients with non-small cell lung cancer. Ann Thorac Surg. 2004;78(3):1017–1023
  21. Cerfolio RJ, Ojha B, Bryant AS, Bass CS, Bartalucci AA, Mountz JM. The role of FDG-PET scan in staging patients with nonsmall cell carcinoma. Ann Thorac Surg. 2003;76(3):861–866
  22. Truong MT, Erasmus JJ, Munden RF, et al. Focal FDG uptake in mediastinal brown fat mimicking malignancy: a potential pitfall resolved on PET/CT. Am J Roentgenol. 2004;183(4):1127–1132
  23. Antoch G, Stattaus J, Nemat AT, et al. Non–small cell lung cancer: dual-modality PET/CT in preoperative staging. Radiology. 2003;229:526–533
  24. Lardinois D, Weder W, Hany TF, et al. Staging of non–small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med. 2003;348:2500–2507

PII: S0899-7071(09)00108-9

doi: 10.1016/j.clinimag.2009.03.012

Clinical Imaging
Volume 34, Issue 1 , Pages 20-28 , January 2010

Article Tools

* Image Usage & Resolution