Clinical Imaging
Volume 34, Issue 1 , Pages 20-28, January 2010

Detection of nodal metastatic disease in patients with non-small cell lung cancer: comparison of positron emission tomography (PET), contrast-enhanced computed tomography (CT), and combined PET-CT

  • Elisa Ventura

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • ,
  • Tina Islam

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • Corresponding Author InformationCorresponding author. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
    • ,
  • Michael S. Gee

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Umar Mahmood

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Marta Braschi

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Mukesh G. Harisinghani

      Affiliations

    • Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    • Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA

Received 6 March 2009; accepted 10 March 2009. published online 10 June 2009.

Abstract 

Of 31 patients with lung cancer, 19 underwent PET-CT and 12 had CT followed by PET. Thoracic lymph nodes were sampled by mediastinoscopy or thoracotomy. Sensitivities, specificities, positive (PPV), and negative predictive values (NPV) were calculated based on histopathology. Ninety nodes (41 malignant) were identified. Sensitivity, specificity, PPV, and NPV were 94%, 73%, 66%, and 96% for PET-CT, respectively. In 12 patients who underwent PET and CT separately, these values were 90%, 31%, 64%, and 71% for PET and 81%, 50%, 69%, and 66% for CT, respectively.

Keywords: Non-small cell lung cancer, Lymph nodes, PET-CT, Diagnostic accuracy

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PII: S0899-7071(09)00108-9

doi:10.1016/j.clinimag.2009.03.012

Clinical Imaging
Volume 34, Issue 1 , Pages 20-28, January 2010

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