Analysis of the mismatched manifestation between rCBF and rCBV maps in cerebral astrocytomas
Received 20 December 2008; accepted 14 January 2009. published online 09 March 2009.
Abstract
Objective
To explore the mismatched manifestation between regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) of astrocytomas.
Methods
Both conventional and perfusion CT were performed on 29 patients with pathologically confirmed astrocytomas (15 cases in Grades I–II, 14 cases in Grades III–IV). Time-density curves were plotted, cerebral blood flow and volume maps were generated, and the values between rCBF and rCBV in the same region of interest (ROI) were compared.
Results
Twelve low-grade astrocytomas showed low or medium values of both rCBF (46.95±22.92 ml ⋅ 100 g−1 ⋅ mm−1) and rCBV (5.74±3.61 ml ⋅ 100 g−1); 12 high-grade astrocytomas showed high values of both rCBF (95.44±42.58 ml ⋅ 100 g−1 ⋅ min−1) and rCBV (9.24±5.32 ml ⋅ 100g−1). These cases exhibited agreement between the values of rCBF and rCBV. However, the remaining five astrocytomas were mismatched, showing reduced rCBF value and increased rCBV value in the same ROI. The discrepancy may mislead to an inaccuracy of perfusion CT in grading gliomas.
Conclusions
The mismatched manifestation between rCBF and rCBV occasionally exists in some areas of astrocytomas. Hence, attention should be paid to assessments in preoperative grading of astrocytomas and in monitoring therapeutic effects.
aImaging Center, The First Affiliated Hospital of Soochow University, No.188, Shizi Street, Suzhou City, Jiangsu Province 215006, People's Republic of China
bImaging Center, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi City, Jiangsu Province 214023, People's Republic of China
Corresponding author. Imaging Center, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Suzhou City, Jiangsu Province, 215006, People's Republic of China. Tel.: +86 512 67780422.
ABSTRACT