Clinical Imaging
Volume 33, Issue 6 , Pages 447-453 , November 2009

Perfusion study of liver lesions with superparamagnetic iron oxide: distinguishing hepatocellular carcinoma from focal nodular hyperplasia

Received 10 November 2008 ,Accepted 14 January 2009.

References 

  1. Itoh K, Nishimura K, Togashi K, Fujisawa I, Noma S, Minami S, et al. Hepatocellular carcinoma: MR imaging. Radiology. 1987;164:21–25
  2. Yamashita Y, Mitsuzaki K, Yi T, Ogata I, Nishiharu T, Urata J, et al. Small hepatocellular carcinoma in patients with chronic liver damage: prospective comparison of detection with dynamic MR imaging and helical CT of the whole liver. Radiology. 1996;200:79–84
  3. Mortele KJ, Praet M, Van Vlierberghe H, Kunnen M, Ros PR. CT and MR imaging finding in focal nodular hyperplasia of the liver: radiologic–pathologic correlation. AJR. 2000;175:687–692
  4. Carlson SK, Johnson CD, Bender CE, Welch TJ. CT of focal nodular hyperplasia of the liver. AJR. 2000;174:705–712
  5. Rogers JV, Mack LA, Freeny PC, Johnson ML, Sones PJ. Hepatic focal nodular hyperplasia: angiography, CT, sonography, and scintigraphy. AJR. 1981;137:983–990
  6. Mathieu D, Bruneton JN, Drouillard J, Pointreau CC, Vasile N. Hepatic adenomas and focal nodular hyperplasia: dynamic CT study. Radiology. 1986;160:53–58
  7. Kudo M, Tomita S, Tochio H, Kashida H, Hirasa M, Todo A. Hepatic focal nodular hyperplasia: specific findings at dynamic contrast-enhanced US with carbon dioxide microbubbles. Radiology. 1991;179:377–382
  8. Miyayama S, Matsui O, Ueda K, Kifune K, Yamashiro M, Yamamoto T, et al. Hemodynamics of small hepatic focal nodular hyperplasia: evaluation with single-level dynamic CT during hepatic arteriography. AJR. 2000;174:1567–1569
  9. Ueda K, Matsui O, Kawamori Y, Nakanuma Y, Kadoya M, Yoshikawa J, et al. Hypervascular hepatocellular carcinoma: evaluation of hemodynamic with dynamic CT during hepatic arteriography. Radiology. 1998;206:161–166
  10. Fukukura Y, Nakashima O, Kusaba A, Kage M, Kojiro M. Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver. J Hepatol. 1998;29:470–475
  11. Stark DD, Weissleder R, Elizondo G, Hahn PF, Saini S, Todd LE, et al. Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology. 1988;168:297–301
  12. Yamamoto H, Yamashita Y, Yoshimatsu S, Baba Y, Hatanaka Y, Murakami R, et al. Hepatocellular carcinoma in cirrhotic livers: detection with unenhanced and iron oxide-enhanced MR imaging. Radiology. 1995;195:106–112
  13. Tanaka M, Nakashima O, Wada Y, Kage M, Kojiro M. Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology. 1996;24:807–812
  14. Precetti-Morel S, Bellin MF, Ghebontni L, Zaim S, Opolon P, Poynard T, et al. Focal nodular hyperplasia of the liver on ferumoxides-enhanced MR imaging: features on conventional spin-echo, fast spin-echo and gradient-echo pulse sequences. Eur Radiol. 1999;9:1535–1542
  15. Ichikawa T, Arbab AS, Araki T, Touyama K, Haradome H, Hachiya J, et al. Perfusion MR imaging with a superparamagnetic iron oxide using T2-weighted and susceptibility-sensitive echoplanar sequences: evaluation of tumor vascularity in hepatocellular carcinoma. AJR. 1999;173:207–213
  16. Saito K, Shindo H, Ozuki T, Ishikawa A, Kotake F, Shimazaki Y, et al. Perfusion study of hypervascular hepatocellular carcinoma with SPIO. Magn Reson Med Sci. 2005;4:151–158
  17. Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T. Characterization of hepatic lesions by perfusion-weighted MR imaging with an echoplanar sequence. AJR. 1998;170:1029–1034

PII: S0899-7071(09)00016-3

doi: 10.1016/j.clinimag.2009.01.008

Clinical Imaging
Volume 33, Issue 6 , Pages 447-453 , November 2009

Article Tools

* Image Usage & Resolution