Clinical Imaging
Volume 25, Issue 5 , Pages 303-308 , September 2001

Can tamoxifen cause a significant mammographic density change in breast parenchyma?

  • Orhan Konez

      Affiliations

    • Department of Radiology, Mercy Medical Center, Northeastern Ohio Universities College of Medicine (NEOUCOM), Mercy Dr. NW, Canton, OH 44708, USA
    • Department of Radiology, Aultman Hospital, Northeastern Ohio Universities College of Medicine (NEOUCOM), Canton, OH, USA
    • Corresponding Author InformationCorresponding author. Current address: Department of Radiology, Beth Israel Deaconess Medical Center 330 Brookline Avenue, Boston, MA 02215. Tel.: 617-667-2523; fax: 617-754-2545
    • ,
  • Manish Goyal

      Affiliations

    • Current address: Saskatoon city hospital, Queen street, Saskatoon, SK, CANADA.
    • Department of Radiology, Mercy Medical Center, Northeastern Ohio Universities College of Medicine (NEOUCOM), Mercy Dr. NW, Canton, OH 44708, USA
    • Department of Radiology, Aultman Hospital, Northeastern Ohio Universities College of Medicine (NEOUCOM), Canton, OH, USA
    • ,
  • Robert E. Reaven

      Affiliations

    • Department of Radiology, Mercy Medical Center, Northeastern Ohio Universities College of Medicine (NEOUCOM), Mercy Dr. NW, Canton, OH 44708, USA

Received 1 May 2001

References 

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  2. Stomper PC, Van Voorhis BJ, Ravnikar VA, Meyer JE. Mammographic changes associated with postmenopausal hormone replacement therapy: a longitudinal study. Radiology. 1990;174:487–490
  3. Berkowitz JE, Gatewood OMB, Goldblum LE, Gayler BW. Hormonal replacement therapy: mammographic manifestations. Radiology. 1990;174:199–201
  4. Meyer JE, Frenna TH, Polger M, Sonnenfeld MR, Shaffer K. Enlarging occult fibroadenomas. Radiology. 1992;183:639–641
  5. Rand T, Heytmanek G, Seifert M, Wunderbaldinger P, Kreuzer S, Schneider B, et al. Mammography in women undergoing hormone replacement therapy. Acta Radiol. 1997;38:228–231
  6. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998;339:1609–1618
  7. Dewar JA, Horobin JM, Preece PE, Tavendale R, Tunstall-Padoe H, Wood RA. Long-term effects of tamoxifen on blood lipid values in breast cancer. Br Med J. 1992;305:225
  8. Cuenca RE, Giachino J, Arredondo MA, Hempling R, Edge SB. Endometrial carcinoma associated with breast carcinoma: Low incidence with tamoxifen use. Cancer. 1996;77(10):2058–2063
  9. Scottish Breast Cancer Committee McDonald CC, Steward HJ. Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial. Br Med J. 1991;303:435
  10. Love RR, Mazess RB, Tormey DC, Barden HS, Newcomb PA, Jordan VC. Bone mineral density in women with breast cancer treated with adjuvant tamoxifen for at least two years. Breast Cancer Res Treat. 1988;12:297
  11. Ward RL, Morgan G, Dalley D, Kelly PJ. Tamoxifen reduces bone turnover and prevents lumber spine and proximal femoral bone loss in early postmenopausal women. Bone Miner. 1993;22:87
  12. Ursin G, Pike MC, Spicer DV, Porrath SA, Reitherman RW. Can mammographic densities predict effects of tamoxifen on the breast?. J Natl Cancer Inst. 1996;88(2):128–129
  13. Taylor C, Georgian-Smith D. Regression of breast cancer in four patients treated with tamoxifen: mammographic features. AJR, Am J Roentgenol. 1994;162:613–616
  14. Fisher B, Costantino J, Redmond C, Poisson R, Bowman D, Couture J, et al. A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors. N Engl J Med. 1989;320:479–484
  15. Fisher B, Dignam J, Bryant J, DeCillis A, Wickerham DL, Wolmark N, et al. Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. J Natl Cancer Inst. 1996;88:1529–1542
  16. Hurst JL, Mega JF, Hogg JP. Tamoxifen-induced regression of breast cysts. Clin Imaging. 1998;22:95–98

PII: S0899-7071(01)00329-1

Clinical Imaging
Volume 25, Issue 5 , Pages 303-308 , September 2001

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